Worldwide

1x1 tACS Device

Industry standard alternating current stimulation

The Soterix Medical 1×1 is the clinical standard device when precision and safety cannot be compromised. The Open-Panel™ control panel allows simple set-up and monitoring. Exclusive features including SmartScan™, Relax™, and TrueCurrent™ ensure every run is successful.

Soterix Medical 1×1 tACS

The only stimulator designed for transcranial Alternating Current Stimulation.
The 1×1 line of Soterix Medical tACS systems provide the most advanced stimulation technology in an intutive user interface.

The Soterix Medical tACS advantage

The Soterix Medical 1×1 tACS device adopts the same engineering and design principles that established the 1x1 tACS devices as the industry standard. 1x1-tACS is designed to provide the following unique features

1×1 tACS

The Soterix Medical 1×1 tACS device adopts the same engineering and design principles that established the 1x1 tDCS (Direct Current Stimulation) devices as the industry gold-standard. For 5 years, the 1x1 platform provides industry leading quality, precision, and usability. Reliable devices are critical exactly because waveform errors can go un-noticed, invalidating all data collected and putting subjects at risk. Researchers and clinicians choose the 1x1 when quality, data integrity, and safety cannot be compromised.

Precision and consistency

Un-paralleled control of alternating signal (AC) fidelity. A clean and precise waveform underpins reproducibility. Validated using realistic loads, the Soterix Medical 1x1 tACS is the trusted standard for unmatched precision. All stimulators are not made equal and the 1x1 tACS guarantees clean sinusoidal output even under non-ideal conditions. The neurophysiological, and so behavioral, effects of tACS are underpinned by the fidelity of the waveform.

Open-panel design

Focus on the trial and on your subjects, not on the device. No drop down menus. No complex hidden features. No need to a separate computer. The Soterix Medical Open-Panel design principle means all settings a trivial to program and all status items clear and backlit. Programming the device is as simple as setting peak current and frequency A simple set-up is not just fast but the best way to prevent costly errors. While 1x1 easy-to-read backlit displays give you confidence from start to finish.

Validated headgear and accessories for tACS

Soterix Medical designs and tested accessories for each stimulation configuration. The same 1x1 accessories that have defined the standard for tolerability in tDCS are adapted for tACS. Single use electrodes designed for non-invasive stimulation means clinical standards for cleanliness, tolerability, and unmatched trial rigor including sham reliability. Soterix Medical’s exclusive 1x1 headgear allow fast and consistent set-up, making it the system of choice in the largest and more rigorous clinical trials. Based on the principle that “In Advanced Neuromodulation One Size Does Not Fit All”, our accessories need to be designed and tested for tACS.

Unique features and special waveforms

Available on select models, unique usability features such as RELAX, TICKLE, TRUEcurrent, and SMARTscan-AC all re-designed and optimized for tACS. In addition to waveform and intensity control, the 1x1 tACS allows users to select conventional biphasic mode or monophasic mode. SMARTscan-AC is the only impedance monitoring system that reliably tracks electrode performance during AC stimulation. Soterix Medical provides expert advice on setting up and implementing tACS.

About transcranial Alternating Current Stimulation

Basics of tACS: Transcranial Alternating Current Stimulation (tACS) involved application of a low-intensity sinusoid (<2 mA) across electrode placed the head. This causes low-intensity electric field to oscillate across a targeted brain region. The frequency of this oscillation is set by the frequency of the AC source, which can be easily adjusted on the Soterix Medical 1-1-tACS. Which regions are targeted can be controlled by using 1x1 Accessories and Soterix Medical Neurotargeting software.

Neuromodulation: The ability of these low-intensity current to entrain oscillations and neurons makes tACS a potential powerful neuromodulatory tool. Researchers and clinicians hypothesize that tACS provides unique capabilities to alter the brain and behavior. Selecting the frequency and intensity of stimulation, as well as electrode locations, is thus fundamental to determine outcome. The Soterix Medical 1x1 tACS allow precise reproduction of all established tACS protocols, as well as the power flexibility to explore new dose paradigms.

Tolerability of tACS: Proper protocols, accessories, and equipment are required for reproducible and tolerated transcranial electrical stimulation. Soterix Medical optimizes systems for each techniques (“In Advanced Neuromodulation One Size Does Not Fit All”) and tACS requires special consideration. Published human trials with tACS indicate the technique is well tolerated when professional standards and equipment is used. This includes stimulators that provide precise output even under load variation and moreover are engineering to prevent transient under none-ideal conditions such as sudden changes in impedance (e.g. do to subject movement). All this technology is automatic with the Soterix Medical 1x1 tACS allowing you to focus on the subject, not on the device. Adverse events associated with tACS include redness (erythema) under and around electrodes, tinging of the scalp during stimulation, and in some cases posphenses (a phenomenon characterized by the experience of seeing light without light actually entering the eye.) The first two are controlled through used of quality single-use electrodes such as the Soterix Medical EasyPads. Posphense are not hazardous and in most cases of retinal origin during tACS - this means that can be minimized by using montages that limit current flow across the eyes. Simulation software can be used for this purpose including Soterix Medical Neurotargeting.

Oscillations of the brain: Rhythmic neuronal activity is ubiquitous in the human brain. These rhythms originate from a variety of different network mechanisms, which give rise to a wide-ranging spectrum of oscillation frequencies. In the last few years an increasing number of clinical research studies have explored transcranial alternating current stimulation (tACS) with weak current as a tool for affecting brain function. The premise of these interventions is that tACS will interact with ongoing brain oscillations.

tACS is unique: tACS is unlike tDCS because the waveform oscillates. tACS is unlike Cranial Electrotherapy Stimulation; as tACS provides a well defined and know signal to entrain brain activity. Cranial Electrotherapy Stimulation devices provide diverse and often poorly defined pulse trains with limited control on montage and brain targeting. tACS is unlike invasive techniques that use high-intensity pulses, because it provide a smooth modulation not possible with pulses. Soterix Medical 1x1-tACS is designed based on scientific principles of AC modulation and is the only device specially designed for tACS.

Oscillations and behavior: Researchers understand that oscillations are ubiquitous in the human brain, ranging from ultra-slow (0.05 Hz) to ultra-fast oscillations (500 Hz). These oscillations occur in the brain during different behavioral states and their power (amplitude) is commonly modulated during cognitive/behavioral tasks. Moreover, abnormal brain rhythms have also been shown to correlate with pathological conditions, like Parkinson’s disease, Alzheimer’s and epileptic seizures. Researcher design tACS on the assumption that modulating brain rhythms has the potential to affect cognitive performance and may be used to treat neurological disorders. Therefore, picking the right stimulation output, and choosing a device that generates signal with high fidelity, underpins tACS. Soterix Medical biomedical engineers are ready to work with you on trial design and our unique HDexplore software provides modules design and optimize tACS electrode placement to target brain regions.

Research grade equipment: At the singe cell level weak AC current applied to the brain will sinusoidally alter the transmembrane potential. Which each cycle of the sinusoid the membrane polarizes up and down. The frequency of tACS set how quickly the membrane oscillations while the peak intensity of tACS sets the peak membrane polarization. But in the brain neurons are not isolated, they are tightly coupled by synapses and in fact work together to generate oscillations. In such situation, weak AC current can modulate the oscillations potentially increasing their power. Many questions remain about the mechanisms of tACS and Soterix Medical is proud to provide the most state-of-the-art stimulator to support this research.

Resources

Soterix Medical’s commitment to stimulation precision and control

Industry Standard For Clinical Trials

The Soterix Medical 1×1 was developed by clinical researchers, scientists, and biomedical engineers to provide all clinical standard tACS protocols. Current intensity from 0.5 to 2 mA, and current duration from 5 to 40 minutes. Stimulation set-up is straight-forward with the simple to set-up Open-Panel™ controls, 1×1 electrode accessories, and SmartScan™ indicator. The tACS 1×1 features allow you to focus on the subject and experiment, not the device.

Our scientific team is ready to work with you to determine optimal dose parameters and accessories.

Request Product Information Manual & Specifications

Exclusive Features

Each Soterix Medical 1×1 feature was developed by our team of biomedical engineers consulting closely with leading clinical centers. Designed to simply set-up, provide intelligent warning of a fault condition, and allow for adjusting for patient comfort , these features facilitate reliable and tolerated tACS. The Soterix Medical SmartScan™ feature is central in all tACS devices to allow reliable set-up and monitoring. The Relax™, Tickle™, and TrueCurrent™ innovations were developed for the 1×1 tACS.

Provides a continuous visual indication of electrode quality before and during stimulation.

From pre-stimulation set-up, to during stimulation monitoring, to post-stimulation confirmation, the Soterix Medical SmartScan™ feature provides an intuitive and clear indication of electrode contact quality. Use the SmartScan™ during set-up to adjust electrodes and head-gear for optimal fit. During stimulation, SmartScan™ provides a constant indication of electrode quality and can be monitored during adjustments (e.g. addition of saline to drying electrodes). After stimulation, SmartScan™ confirms a successful trial. Because “resistance” is not meaningful for tACS, SmartScan™ was developed by Soterix Medical engineers to provide clinical investigators with a simple to read indication of contact quality.

Clearly indicates the actual current supplied at the moment.

What other devices promise, the 1×1 tACS delivers. The back-lit display can be monitored during stimulation ramp up and to confirm target current intensity is achieved.

May be used to supply a very weak current prior to tACS to help condition the skin.

Tickle™ may be used to both condition skin prior to tACS and for naïve subject anxious about stimulation. A custom on-off waveform pattern generates mild and brief sensation under electrodes.

Allows the clinician to use a simple sliding bar to transiently decrease the current from the pre-set value, for example based on subject feedback.

Based on feed-back from leading clinical centers, Soterix Medical exclusive feature Relax™ accommodates subjects who may be anxious when stimulation is initiated or during the course of stimulation. The Relax™ slider may be adjusted from full to reduced intensity based on subject perception without interrupting or aborting stimulation.

Simple and intelligent sham waveforms.

An automatic stimulation sham feature that is engaged with a simple switch. Auto-sham automatically calculated and produces a sham waveform based on the the indicated “real” waveform. For example, for a corresponding real waveform of 1.5 mA and 10 minutes. auto-sham will provide a ramp up/down to 1.5 mA at the start of of stimulation, and again after 10 minutes, with the timer automatically adjusted such that the total run time us exactly matched to the real case. Based on the Soterix Medical OpenPanelTM design principle: with no complicated programming or hidden drop-down menus required.

Compatibility with monitoring technology

With increased interest in the use of monitoring, such as EEG, PET, MEG, Eye-tracking, NIR and fMRI in conjunction with tACS, Soterix Medical remains the only company with the technology and expertise to ensure successful integration. Stimulation generates artifacts in all monitoring modalities including fMRI (Antal A et. al 2012), such that use of technically compatible devices without also integrating rational trial design, can lead to errant findings.

Soterix Medical biomedical engineers are available to discuss the combination of rational measurement with our industry standard 1x1 platform. And only Soterix Neurotargeting allows co-registration of current flow and measured responses

Imaging artifacts induced by electrical stimulation during conventional fMRI of the brain. Antal A, Bikson M, Datta A, Lafon B, Dechent P,Parra LC, Paulus W

Email: SMI Clinical Trial Design Support

Rational Integration of Soterix 1×1 tDCS with PET.

Rational Integration of Soterix 1×1 tDCS with PET.

Rational Integration of Soterix 1×1 tDCS with PET.

Rational Integration of Soterix 1×1 tDCS with PET.


Fully compatible and expandable with all Soterix Medical 1x1 accessories

Every 1×1 accessory is optimized for simple and consistent set-up, robust and safe performance, and ease of use. Since "one size does not fit all" in tES, the 1×1 accessory set provides the flexibility to optimize performance. From EASYpads™ to EASYstraps™ Soterix Medical 1×1 accessories are designed and validated specifically for the 1×1 platform. Our scientific team is ready to help you select the best accessory set to make your 1×1 the most optimized platform adjustable to any application.

EASYpads

The first electrode optimized for tDCS/tPCS/tACS/tRNS and related technologies for comfortable and consistent stimulation.

Elastic fasteners

Designed for simple, rapid and flexible trial setup.

EASYstraps

Designed for maximizing reproducibility and subject comfort for all standard tDCS/tPCS/tACS/tRNS locations.

EASYkits

Everything that you need for a complete tDCS/tPCS/tACS/tRNS session.

EASYcase

The most safe and portable way to transport everything you need for tDCS/tPCS/tACS/tRNS

Clinical Neuromodulation Cart

Accessible storage for all your 1x1 devices.

Break-out Box

Breakout boxes are designed to provide a simple-to-use and reliable extension to your 1x1 device with minimal additional cost.

tACS Software

Optimization of electrode montage for brain targeting and individual subject customization has never been as easier as with Soterix Medical's Neurotargeting software. With recognition that placing an electrode "over" a target does not support rational tACS does design, the Soterix Medical Suite of software tools allow simple and automatic optimization. Soterix Neurotargeting software also provides high-resolution current flow visualization that can be used to support publications, presentation and proposals.
Note “HD-explore” allow simulation of any conventional tACS montage with minor allowances for frequency specific tissue conductivity

Caution! Investigational Device. Federal (or United States) law limits device to investigational use.