The Soterix Medical 1×1 is the clinical standard device when precision and safety cannot be compromised. The Open-Panel™ control panel allows simple set-up and monitoring. Exclusive features including SMARTscan™, RELAX™, and TrueCurrent™ ensure every run is successful.
The Soterix Medical 1x1 tACS device adopts the same engineering and design principles that established the 1x1 tDCS devices as the industry standard. 1x1-tACS is designed to provide the following unique features
The Soterix Medical 1×1 tACS device adopts the same engineering and design principles that established the 1x1 tDCS (Direct Current Stimulation) devices as the industry gold-standard. For 5 years, the 1x1 platform provides industry leading quality, precision, and usability. Reliable devices are critical exactly because waveform errors can go un-noticed, invalidating all data collected and putting subjects at risk. Researchers and clinicians choose the 1x1 when quality, data integrity, and safety cannot be compromised.
Un-paralleled control of alternating signal (AC) fidelity. A clean and precise waveform underpins reproducibility. Validated using realistic loads, the Soterix Medical 1x1 tACS is the trusted standard for unmatched precision. All stimulators are not made equal and the 1x1 tACS guarantees clean sinusoidal output even under non-ideal conditions. The neurophysiological, and so behavioral, effects of tACS are underpinned by the fidelity of the waveform.
Focus on the trial and on your subjects, not on the device. No drop down menus. No complex hidden features. No need to a separate computer. The Soterix Medical Open-Panel™ design principle means all settings are easy to program and all status items are clear and backlit. Programming the device is as simple as setting peak current and frequency. A simple set-up is not just fast but the best way to prevent costly errors. While 1x1 easy-to-read backlit displays give you confidence from start to finish.
Soterix Medical designed and tested accessories for each stimulation configuration. The same 1x1 accessories that have defined the standard for tolerability in tDCS are adapted for tACS. Single use electrodes designed for non-invasive stimulation means clinical standards for cleanliness, tolerability, and unmatched trial rigor including sham reliability. Soterix Medical’s exclusive 1x1 headgear allow fast and consistent set-up, making it the system of choice in the largest and more rigorous clinical trials. Based on the principle that “In Advanced Neuromodulation One Size Does Not Fit All”, our accessories need to be designed and tested for tACS.
Available on select models, unique usability features such as RELAX™, TICKLE™, TRUEcurrent™, and SMARTscan™-AC are re-designed and optimized for tACS. In addition to waveform and intensity control, the 1x1 tACS allows users to select conventional biphasic mode or monophasic mode. SMARTscan-AC is the only impedance monitoring system that reliably tracks electrode performance during AC stimulation. Soterix Medical provides expert advice on setting up and implementing tACS.
Basics of tACS: transcranial Alternating Current Stimulation (tACS) is a low-intensity sinusoid (<2 mA) current across an electrode placed on the head. This causes a low-intensity electric field to oscillate across a targeted brain region. The frequency of this oscillation is set by the frequency of the AC source, which can be easily adjusted on the Soterix Medical 1×1 tACS. The targeted regions can be controlled by using 1x1 Accessories and Soterix Medical Neurotargeting software.
Neuromodulation: The ability of a low-intensity current to entrain oscillations and neurons makes tACS a potential powerful neuromodulatory tool. Researchers and clinicians hypothesize that tACS provides unique capabilities to alter the brain and behavior. Selecting the frequency and intensity of stimulation, as well as electrode locations, is fundamental in determining the outcome. The Soterix Medical 1x1 tACS allows precise reproduction of all established tACS protocols, as well as the flexibility to explore new dose paradigms.
Tolerability of tACS: Proper protocols, accessories, and equipment are required for reproducible and tolerated transcranial electrical stimulation. Soterix Medical optimizes systems for each technique (“In Advanced Neuromodulation One Size Does Not Fit All”) and tACS requires special consideration. Published human trials with tACS indicate that the technique is well tolerated when professional standards and equipment is used. This includes stimulators that provide precise output, even under load variation, and moreover, are engineered to prevent transient under non-ideal conditions, such as sudden changes in impedance (e.g. do to subject movement). All this technology is automatic with the Soterix Medical 1x1 tACS, allowing you to focus on the subject, not on the device. Adverse events associated with tACS include redness (erythema) under and around electrodes, tingling of the scalp during stimulation, and in some cases phosphene (a phenomenon characterized by the experience of seeing light without light actually entering the eye.) The first two are controlled through use of quality single-use electrodes, such as the Soterix Medical EasyPads. Phosphines are not hazardous and in most cases are of retinal origin during tACS - this means that they can be minimized by using montages that limit current flow across the eyes. Simulation software can be used for this purpose including Soterix Medical Neurotargeting.
Oscillations of the brain: Rhythmic neuronal activity is ubiquitous in the human brain. These rhythms originate from a variety of different network mechanisms, which give rise to a wide-ranging spectrum of oscillation frequencies. In the last few years an increasing number of clinical research studies have explored transcranial alternating current stimulation (tACS) with weak current as a tool for affecting brain function. The premise of these interventions is that tACS will interact with ongoing brain oscillations.
tACS is unique: tACS is unlike tDCS because the waveform oscillates. tACS is unlike Cranial Electrotherapy Stimulation; as tACS provides a well-defined and known signal to entrain brain activity. Cranial Electrotherapy Stimulation devices provide diverse and often poorly defined pulse trains with limited control on montage and brain targeting. tACS is unlike invasive techniques that use high-intensity pulses, because it provides a smooth modulation not possible with pulses. Soterix Medical 1x1-tACS is designed based on scientific principles of AC modulation and is the only device specially designed for tACS.
Oscillations and behavior: Researchers understand that oscillations are ubiquitous in the human brain, ranging from ultra-slow (0.05 Hz) to ultra-fast oscillations (500 Hz). These oscillations occur in the brain during different behavioral states and their power (amplitude) is commonly modulated during cognitive/behavioral tasks. Moreover, abnormal brain rhythms have also been shown to correlate with pathological conditions, like Parkinson’s disease, Alzheimer’s, and epileptic seizures. Researchers designed tACS on the assumption that modulating brain rhythms has the potential to affect cognitive performance and may be used to treat neurological disorders. Therefore, picking the right stimulation output, and choosing a device that generates signal with high fidelity, underpins tACS. Soterix Medical biomedical engineers are ready to work with you on trial design. Our unique HDexplore software provides a module design used to optimize tACS electrode placement in order to target brain regions.
Research grade equipment: At the single cell level, weak AC current applied to the brain will sinusoidally alter the transmembrane potential. with each cycle of the sinusoid, the membrane polarizes up and down. The frequency of tACS sets how quickly the membrane oscillates, while the peak intensity of tACS sets the peak membrane polarization. But in the brain, neurons are not isolated. Neurons are tightly coupled by synapses and, in fact, work together to generate oscillations. In such a situation, weak AC current can modulate the oscillations, potentially increasing their power. Many questions remain about the mechanisms of tACS and Soterix Medical is proud to provide the most state-of-the-art stimulator to support this research.
The Soterix Medical 1×1 was developed by clinical researchers, scientists, and biomedical engineers to provide all clinical standard tACS protocols. Current intensity from 0.5 to 2 mA, and current duration from 5 to 40 minutes. Stimulation set-up is straight-forward with the simple to set-up Open-Panel™ controls, 1×1 electrode accessories, and SMARTscan™ indicator. The tACS 1×1 features allow you to focus on the subject and experiment, not the device.
Our scientific team is ready to work with you to determine optimal dose parameters and accessories.
Each Soterix Medical 1×1 feature was developed by our team of biomedical engineers consulting closely with leading clinical centers. Designed to simply set-up, provide intelligent warning of a fault condition, and allow for adjusting for patient comfort , these features facilitate reliable and tolerated tACS. The Soterix Medical SMARTscan™ feature is central in all tACS devices to allow reliable set-up and monitoring. The RELAX™, Tickle™, and TrueCurrent™ innovations were developed for the 1×1 tACS.
Provides a continuous visual indication of electrode quality before and during stimulation.
From pre-stimulation set-up, to during stimulation monitoring, to post-stimulation confirmation, the Soterix Medical SMARTscan™ feature provides an intuitive and clear indication of electrode contact quality. Use the SMARTscan™ during set-up to adjust electrodes and head-gear for an optimal fit. During stimulation, SMARTscan™ provides a constant indication of electrode quality and can be monitored during adjustments (e.g. addition of saline to drying electrodes). After stimulation, SMARTscan™ confirms a successful trial. Because “resistance” is not meaningful for tACS, SMARTscan™ was developed by Soterix Medical engineers to provide clinical investigators with a simple to read indication of contact quality.
Clearly indicates the actual current supplied at the moment.
What other devices promise, the 1×1 tDCS delivers. The back-lit display can be monitored during stimulation ramp up to confirm that the targeted current intensity is achieved.
May be used to supply a very weak current prior to tDCS to help condition the skin.
Tickle™ may be used to both condition skin prior to tDCS and for naïve subject anxious about stimulation. A custom on-off waveform pattern generates mild and brief sensation under electrodes.
Allows the clinician to use a simple sliding bar to transiently decrease the current from the pre-set value, for example, based on subject feedback.
Based on feed-back from leading clinical centers, Soterix Medical exclusive feature, RELAX™, accommodates subjects who may be anxious when stimulation is initiated or during the course of stimulation. The RELAX™ slider may be adjusted from full to reduced intensity based on subject perception without interrupting or aborting stimulation.
Simple and intelligent sham waveforms.
An automatic stimulation sham feature that is engaged with a simple switch. Auto-sham automatically calculated and produces a sham waveform based on the indicated “real” waveform. For example, for a corresponding real waveform of 1.5 mA and 10 minutes. auto-sham will provide a ramp up/down to 1.5 mA at the start of stimulation, and again after 10 minutes, with the timer automatically adjusted such that the total run time is exactly matched to the real case. Based on the Soterix Medical Open-Panel™ design principle: with no complicated programming or hidden drop-down menus required.
Optimization of electrode montage for brain targeting and individual subject customization has never been as easier as with Soterix Medical's Neurotargeting software. With recognition that placing an electrode "over" a target does not support rational tACS does design, the Soterix Medical Suite of software tools allow simple and automatic optimization. Soterix Neurotargeting software also provides high-resolution current flow visualization that can be used to support publications, presentation and proposals.
Note “HD-explore” allow simulation of any conventional tACS montage with minor allowances for frequency specific tissue conductivity