The first fully software-controlled stimulation system with unmatched specifications. The first stimulator that allows simultaneous multiple-region targeting. The first stimulator with sub-gyri targeting. The first stimulator with image-guided neuronavigation. A system so advanced, it could only have been made by Soterix Medical, the world leader in non-invasive neuromodulation and integrated imaging technologies.
It is known that multiple brain regions and networks are involved in the pathogenesis of certain conditions, making it rational to optimize montages that allow simultaneous targeting of these regions. In fact, it has been shown that targeting as many as 5 brain regions, require ~30 electrodes (Huang 2018). Even when targeting just 2 brain regions, fully independent waveform (e.g. frequency) control optimizes neuromodulation (Reinhart and Nguyen 2019).
Targeting on five point-like ROIs (red circles in the MRI on left) or five brain structures (red regions in the MRI on right). Neurotargeting software prescribed optimal electrode placement and current per electrode (green topoplot-Montage colormap). The corresponding targeting result across 5 selected regions are shown on the right (brain false color, Electric Field colormap).
The Soterix Medical M×N 33/65 system is capable of Sub-Gyri targeting with arbitrary waveform. Sub-Gyri current control integrates 3 unique Soterix Medical technologies:
Moreover, with current flow patterns produced by transcranial electrical stimulation modulated by cortex convolutions, and the resulting neuromodulation highly directionally sensitive, Soterix Medical created the only technology capable of sub-gyri specific control of electric field magnitude and direction (Rawji 2018)
Comparison of electric field modeling for montages directing current across and along the cortical surface. Study confirmed that orthogonal, but not parallel, oriented tDCS modulates TMS -MEPs. See Rawji 2018 for more information.
The Soterix Medical M×N 33/65 allows generation of any waveform you want and through any electrode combination you want. The system allows simple selection from common waveforms (tDCS, tACS, tRNS) or loading customized arbitrary waveforms using sample values from a user-provided text file. The system will deliver any standard or arbitrary wave with a remarkable sample period of ~2 𝛍secs. This means no matter what waveform you choose, the M×N 33/65 provide unmatched reliability and fidelity. The system supports Matlab integration to fully control stimulation, standard TTL triggers to start/abort stimulation (either generated by third party triggering solution or by our custom triggering interface), and can be configured to deliver complex protocols (deliver electrical stimulation at a certain delay from an event onset).
The Soterix Medical M×N 33/65 Stimulator allows for the first time - dense stimulation (up to 65 channels) combined with dense recording applications. Leverage our integrated technology solutions to pair with research-grade EEG, fNIRS, PET, fMRI options that you want and trust. Use the full software control option to plan real-time closed-loop application. Use the triggering option to implement experiments that allow closing the loop. Use our unique electrode holders to hold HD-tES / HD-tDCS stimulation electrode and the recording electrode at the same scalp location by either: a) holding both at the same time or b) holding either one, one at a time. The possibilities are endless.