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Redefining the Possibilities with Neuromodulation

High Definition
Transcranial Electrical Stimulation


Optimized Neuromodulation

HD-tES allows targeted non-invasive electrical stimulation.

Soterix Medical developed HD-tES as the first transcranial system capable of targeting the brain with weak electrical stimulation. HD-tES broke conventional thinking that only high-power magnetic or implanted electrodes could achieve focality. Soterix Medical has continued to innovate HD-tES by introducing Neurotargeting software for individualized programing, the first neuronavigation system for tES, and research-grade integration with EEG.

4x1 HD montage allows targeted cortical neuromodulation

HD electrode allows tolerated stimulation with arrays

Neurotargeting algorithm for software optimization

First HD tolerability and clinical trials

Neuronavigation and comprehensive integration with EEG

Verified MRI and PET Compatibility

Customized Neuromodulation

HD-tES provides scalability and flexibility

A programmable multi-channel stimulator is only effective when combined with tools to optimize neuromodulation. All HD systems are compatible with Soterix Medical Neurotargeting software that allows you to develop customized interventions. From 5 to 82 independently controlled stimulation channels, Soterix Medical provides scalable solutions that meet your need and provide expansive flexibility.

Individualized Stimulation

Integration with EEG and Neuronavigation

Soterix Medical HD-tES can be integrated with EEG from 8 to 64 channels. HD-tES is compatible with any research-grade EEG system allowing any Soterix Medical stimulator to be flexibly integrated with EEG systems. HD-tES can also be combined with Neuronavigation using the Soterix Medical Neural Navigator. The Neural Navigator can be integrated with Neurotargeting software to design and deliver individually optimized stimulation.

1) Use HD-Targets to determine optimal electrode placement for your brain target.

2) Load stimulation electrode voxel locations into Neural navigator software.

3) Navigate to stimulation electrode location using individual's MRI and mark location on scalp.


Exclusively from Soterix Medical

Validated Research-Grade HD-tES

From the trusted leader in non-invasive neuromodulation, Soterix Medical HD-tES has been validated in rigorous clinical trials. When stimulation tolerability and reproducibility cannot be compromised researcher and clinicians choose Soterix Medical stimulation systems. All products come with expert Soterix Medical technical Soterix Medical support, documentation, and training. The MxN is the flagship product line from the leader in non-invasive neuromodulation and is backed by Soterix Medical performance guarantees and our unmatched technical support.

All MxN devices are compatible with exclusive HD accessories. The 4x1 HD-tDCS adaptor can upgrade any 1x1 tDCS or 1x1 tES device to 4x1 HD. The MxN-5 and MxN-9 devices provide Open-Panel controls, with no external computer required. The MxN-33 system is a fully software-controlled system with standard and arbitrary waveforms.

Soterix Medical Case Use 4

High-Definition tACS with Neurotargeting: “Working memory in older adults and synchronized rhythmic brain circuits”.

Soterix Medical Case Use reports are provided for information purpose only and the original publications should be consulted for comprehensive details.

Caution! Investigational Device. Federal (or the United States) law limits the device to investigational use

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Breakthrough Features: Unique Capabilities

Researchers at the City University of New York invented the hardware and software for the only non-invasive low-intensity targeted electrical stimulation platform: High-Definition tES (HD-tES). HD-tES hardware and software systems are exclusively produced by Soterix Medical.

Learn more about Neurotargeting Software

Learn more about HD-tES

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Better Technology: Real Outcomes

Used in hundreds of published trials, Soterix Medical technology is the most capable and trusted non-invasive neuromodulation technology. For example, researchers at NYU School of Medicine measured intra-cranial voltages in humans, validating current flow models by using Soterix Medical Neurotargeting software. Soterix Medical hardware has been evaluated across hundreds of thousands of sessions making it the only choice when reproducibility and tolerability cannot be compromised.

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Better science: Real Impact

Reported in Nature Neuroscience “Working memory revived in older adults by synchronizing rhythmic brain circuits.” Investigators leverage exclusive Soterix Medical HD-tES hardware guided by Neurotargeting software. Only Soterix Medical technology allows non-invasive targeting with precise waveform control. New York Times reports “To Improve Memory, Tune It Like an Orchestra”.

Contact Soterix Medical for customized systems


Soterix Medical was founded to support the rigorous science and medicine of non-invasive neuromodulation

Soterix Medical Case Use 5

Sub-Gyri Targeting with HD-tDCS: A new frontier in neuromodulation

Soterix Medical Case Use reports are provided for information purpose only and the original publications should be consulted for comprehensive details.

Caution! Investigational Device. Federal (or the United States) law limits the device to investigational use

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Rigorous science of target engagement

Researchers at University College London publish that changes in motor excitability by HD-tDCS depend on both the direction of DC current flow and which neuronal pathways are probed by TMS. The finding that current flow direction at the sub-gyri scale can 1) be controlled and 2) fundamentally affects outcomes, has broad implications for transcranial electrical stimulation.

Learn more about the most powerful and precise TMS: Mega by Soterix Medical

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Important implications for behavior and learning

Researchers at University College London then show directional effects of HD-tDCS on physiological measures in the motor system would also be observed on motor behaviors. Therefore control of sub-gyri current flow direction can categorically impact behavioral and clinical outcomes of transcranial electrical stimulation.

Basics and history of HD-tDCS

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Image-guided Neuronavigation extends gyri-control across cortex

While use of TMS and motor read-outs allow functional mapping of gyri-anatomy in the motor cortex, for other cortical regions MRI-guided Neuronavigation is used. Integration of Soterix Medical Neuronavigation, Neurotargeting software, and HD stimulators allow sub-gyri (directional) current targeting across individuals and brain regions.

Learn more about the integrated MxN-33 system


Soterix Medical was founded to support the rigorous science and medicine of non-invasive neuromodulation

Caution! Investigational Device. Federal (or United States) law limits device to investigational use.