HD-Explore™ 4.0 with tDCS emulation

Rationally plan HD-tDCS, tDCS and tACS clinical trials

Only from Soterix Medical, HD-Explore allows clinicians and researchers to investigate brain targeting for your own HD configurations. HD-Explore allows clinicians and researchers to rationally plan HD protocols.

  • Combine HD-Explore with custom modeling for individualized analysis.
  • Automatically calculate optimized targets with HD-Targets.
  • Use HD-Explore to explore HD 4x1 stimulation or any HD montage.
  • HD-Explore (Version 4.0) comes pre-loaded with three neurologically normal male Adult heads and the Standard MNI 152 head..
  • Contact SMI for loading additional library heads at any time. For loading your trial specific heads, send SMI your subjects’ anatomical MRI for custom modeling loaded right into HD-Explore.
  • 3D view of segmentation masks of all tissues (new in Version 4.0).
  • 3D solid surface and transparent surface views of current flow (new in Version 4.0).
  • Cutting plane and opacity functions for enhanced visualization and post-processing (new in Version 4.0).
  • Compatible with all Soterix Medical HD-tDCS devices and 1x1 tDCS and tACS devices.

Simple to use HD-Explore interface

Manual & Specifications

HD-Explore 1, 2, 3


Select a head from the Soterix model library
Adult (male, female), pediatric, stroke, custom models.

MNI Standard Head Electrode Model

Pediatric Head: White Matter

Gray Matter of Stroke Patient

Bone View of Stroke Patient


Select the HD or sponge electrode montage
Simply click the electrode location and enter the amount of current

Pad Configuration: F3 / F4 Montage

Flexible Layout Configurations


Visualize current flow through the head
Use the simple tools to plot current density across the brain

3D View

Transparent View

Selecting A Cutting Plane

Sliced Brain

Current Flow

NEW with Version 4.0 and higher:

3D visualization of segmentation masks. 3D visualization of solid surface and transparent surface of brain current flow. Ability to use cutting planes to visualize fields inside the brain at the location of the cut. Ability to use opacity function to visualize current flow within the whole 3D volume.

Simulate any tDCS or tACS montage with HD-Explore

Another innovation from Soterix Medical Neurotargeting. Users of HD-Explore can now emulate any conventional (pad) tDCS/tACS montage: any number of pads, any shape and size, and position on the head. HD-Explore allows you to simply select a set of HD-electrodes that cover the same region as the emulated pad to re-create brain current flow produced by the pad. Simulate any existing or new tDCS/tACS montage. And combine any number of tDCS/tACS or HD-tDCS electrodes with any current. The limit is your imagination.

A modeling tool-box to build on

Included in HD-Explore 3.1

Standard MNI head and three adult heads.

Standard MNI 152 and one Adult head below.

Individual modeling

Upload your MRI to our server and the model is downloaded straight to your HD-Explore

Separate purchase required.

Acquire additional heads from the SMI library

Stroke (varied lesions)
Low/high BMI
Skull defects

Separate purchase required.

Soterix Medical Case Use

Understanding Semantic Integration with targets High-Definition tDCS

Soterix Medical Case Use reports are provided for information purpose only and the original publications should be consulted for comprehensive details.

Caution! Investigational Device. Federal (or United States) law limits device to investigational use


Neurotargeted Montage:

Using Soterix Medical’s exclusive Neurotargeting software, HD-Explore, research optimized High-Definition tDCS to target the angular gurus. High-Definition tDCS, an exclusive Soterix Medical Technology, uses HD electrode arrays to maximize brain targeting. Here, researchers at the University of Pennsylvania were able to designed a 4x1 montage that maximizes targeting. HD-Explore is simple to use and runs on a conventional laptop, yet the results are compatible to state-of-the-art computational lab approaches.


Rigorous Science:

Published in the Journal of Neuroscience, the University of Pennsylvania teams discover a causal role of the left angular gyrus in lexical-semantic integration which provides motivation for novel therapeutic applications in patients with lexical-semantic deficits. This discovery is only possible using focal HD-tDCS which is the only target and sub-threshold neuromodulation approach. Only though targeted and specific neuromodulation could the the angular gyrus have been isolated. Conventional tDCS lacks the focality needed for angular gyrus stimulation and TMS will lead to supra-threshold secondly activation.


Real Impact:

Several news agencies highlight both the scientific and clinical impact of this work including Science Daily and John Hopkins News. The combination of scientific innovation and state-of-the-art technology (Soterix Medical HD-Explore and HD-tDCS) make this work foundational. Because a brain region was directly implicated using targeted sub-threshold neuromodulation, the work establishes a foundation for ongoing exploration of brain function and treatment options.

Soterix Medical was founded to support the rigorous science and medicine of non-invasive neuromodulation

Caution! Investigational Device. Federal (or United States) law limits device to investigational use.