The RK-50 is a preclinical FUS system capable of delivering precise ultrasound exposures in the rodent brain. The system includes everything you need to start ultrasound brain studies out of the box. The arbitrary waveform generator allows the generation of precise waveforms and ensures synchronized operation. Targeting is achieved using a rodent digital brain atlas and stereotactic methods, or with MRI using a custom attachment. The 3-axis positioning system with the stereotactic frame ensures fast and precise multi-point targeting. The RK-50 uses real-time acoustic feedback with a built-in hydrophone to ensure rigorous and repeatable application. The system can be configured to work on a benchtop or on a laboratory cart.